During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a connector ...

Replication origins in eukaryotic cells initiate a single round of DNA synthesis in each cell cycle. This requires the regulated binding of several conserved initiation proteins, including CDC6/Cdc18p ...

USC researchers peering deep inside a living cell have discovered something surprising: Its system for preventing genetic damage linked to diseases can fail so badly that the cell would be better off ...

When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem - a failsafe that is critical to maintaining health and staving off ...

The eukaryotic intra-S-phase checkpoint, which slows DNA synthesis in response to DNA damage, is poorly understood. Is DNA damage recognized directly, or indirectly through its effects on replication ...

The DNA damage response is essential for maintaining genome integrity. When DNA damage or replication stress occurs, a checkpoint signaling pathway is activated to arrest the cell cycle and initiate ...

This is a preview. Log in through your library . Abstract In eucaryotic cells chromosomes must be fully replicated and repaired before mitosis begins. Genetic studies indicate that this dependence of ...

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert ...

When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem -- a failsafe that is critical to maintaining health and staving off ...