This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

Figure 1: The number of human germline microsatellite mutations in relation to standardized allele size. The absence of an allele-span effect is problematic for theories invoking heterozygote ...

A phylogenetic tree of SARS-CoV-2 sequences, built with Nextstrain, displays sequences colored by their clade and organized by collection date. Over time, sequences mutate and diverge, forming new ...

In a recent study published in the journal Nature Communications, researchers discovered a family with a germline-encoded telomere template sequence mutation (TTAGGT) in telomerase, which results in a ...

When scientists investigate the spread of an infectious disease, one area they look at is the genetic sequences of the pathogen. But there’s a snag when it comes to the monkeypox virus, which is now ...

Research in next-generation sequencing (NGS) is rapidly evolving, especially in several areas of cancer research that rely on detection of mutations. In contrast to germline mutations, somatic ...

Modeling the cost-effectiveness of granulocyte colony-stimulating factor use in early-stage breast cancer. A total of 238 women with breast cancer before age 50 or ovarian cancer at any age and at ...

RAS genes constitute the most regularly mutated oncogene family in cancer. Indeed, RAS genes constituted the most regularly mutated oncogenes in the top three causes of cancer deaths in the US in 2016 ...

Scientists say they have found a pattern of so-called epigenetic 'marks' in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a ...

DNA sequencing refers to the process of identifying the order of bases in a strand of DNA. DNA is comprised of nucleotides, with each nucleotide consisting of a sugar, a phosphate group and a base.