Our study progresses from the rational design of polyplex micelles to the mechanistic elucidation of mRNA degradation, revealing RNase infiltration—rather than carrier dissociation—as the principal ...
Different variants of a gene, known as isoforms, can be transcribed and translated at varying levels within a cell or tissue. These isoforms are commonly a result of alternative splicing, which ...
Fig. 2 Examples of ionizable lipids, sterols, phospholipids, and PEG-lipids used in LNP formulations. Created with BioRender.com. Fig. 3 High-throughput screening of the 3-component ionizable ...
Among the vastly different ways of tackling a disease, controlling the genetic expression of cells is undoubtedly one of the most powerful. Over the past few decades, scientists have come up with ...
mRNA molecule, illustration. [Kateryna Kon/Science Photo Library/Getty Images] Messenger RNA (mRNA) has already transformed medicine, most notably through COVID‑19 vaccines that taught cells to act as ...
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