Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation ...

Clinical research has long focused on ways to harness the actions of the immune system. From vaccines to immunotherapies, researchers have used their knowledge of the immune system to develop ...

The BCG vaccine protects against tuberculosis, but by inducing trained immunity it also protects against many more respiratory infections. International research led by the Radboudumc shows how this ...

When thinking about the immune system, most people think about B and T cells and how they can be trained to recognize pathogens, preventing re-infections. Besides this "adaptive" immune system, we ...

Researchers from Penn’s School of Dental Medicine discovered that training the innate immune system may lead to increased bone loss in inflammatory conditions such as periodontitis and arthritis.

Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis. Clinical ...

Exposure to a common fungal molecule can reprogram immune cells in the lungs, causing them to overreact to infection-like signals and worsen lung damage, according to new research. The study, ...