Describes acid-base physiology and discusses the diagnosis and treatment of disorders associated with metabolic acidosis and metabolic alkalosis, as well as plasma potassium disorders. Metabolic ...

Acute metabolic acidosis is associated with increased morbidity and mortality because of its depressive effects on cardiovascular function, facilitation of cardiac arrhythmias, stimulation of ...

Antibiotics are among the most frequently prescribed drugs in medicine. Their use, however, is often limited by associated renal toxic effects. The most common manifestation of these toxic effects is ...

The bioenergetics of lactate generation can be summarized as follows: glucose + 2(ADP + inorganic phosphate) → 2 lactate + 2 H + + 2 ATP. Production of lactate ions by means of glycolysis is ...

To the Editor: In the June 20 issue of the Journal, Schwartz and Relman present an article on acid–base disorders in which they criticize some newer parameters used in their evaluation. A criticism by ...