Inflammatory bowel disease (IBD) is typically diagnosed after the onset of symptoms in the context of established, characteristic patterns of intestinal inflammation. However, there is now substantial ...

Background RNA 5-methylcytosine (m 5 C) has emerged as a critical epigenetic regulator in cancer biology, yet its role in the tumour immune microenvironment (TME) remains incompletely understood.

We read with great interest the recent article by Turner et al published in Gut , which evaluated the use of faecal calprotectin to define preclinical stages of Crohn’s disease (CD) in asymptomatic ...

Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan Dr H Isomoto, Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 ...

Background Existing scales for assessing faecal incontinence have not been validated against clinical assessment, or with regard to reproducibility. They also fail to take into account faecal urgency, ...

15 Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore Background Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of the general ...

3 Mater Pathology, Mater Health Services, South Brisbane, Queensland, Australia 4 Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland, Australia 5 Queensland Institute ...

2 Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China Background Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options and poor ...

Correspondence to Professor Xiao Xu, Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China; ...

Objective The antiviral efficacy of nucleos(t)ide analogues whose main limitation is relapse after discontinuation requires long-term therapy. To overcome the risk of relapse and virological ...

Objective Endoscopic full-thickness resection (EFTR) is a novel treatment of colorectal lesions not amenable to conventional endoscopic resection. The aim of this prospective multicentre study was to ...

Objective To estimate the proportion of cases of Crohn’s disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Design In a prospective cohort study of US ...