New research co-led by Indiana University School of Medicine scientists has exposed a vulnerability in acute myeloid leukemia by identifying the blood cancer's reliance on a specific signaling pathway ...

A new human study has uncovered how the body naturally turns off inflammation. Researchers found that fat-derived molecules called epoxy-oxylipins rein in immune cells that can otherwise drive chronic ...

The understanding of how macrophages regulate their response to toxic particles via two independent pathways could uncover therapeutic opportunities to quell inflammation BIRMINGHAM, Ala. – Human ...

The findings suggest that dampening eosinophilic and T2 inflammatory responses result in increases in several alternative inflammatory pathways that contribute to residual exacerbations in children ...

Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.

Inflammation can feel like a localized fever, with redness, pain, heat and swelling. It’s how the body works to protect you after an injury, removing damaged tissue or invading bacteria and beginning ...

A certain biological pathway drives the inflammation seen in the skin disease psoriasis. A certain biological pathway, a set of linked reactions in the body, drives the inflammation seen in the skin ...

Cortisol, the primary glucocorticoid hormone, plays a central role in the body's stress response and immune regulation. Released by the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis ...

Macrophages are the specialized phagocytic cells that respond to toxic particle depositions to exert inflammatory and clearance responses. These long-lived immune cells engulf foreign substances like ...