Artificial intelligence has solved one of biology’s most stubborn mysteries: how proteins fold into their intricate three-dimensional shapes. But as the field shifts from prediction to application, a ...

Inspired by the simple mechanism of a seesaw—when one side goes up, the other side goes down—researchers asked an intriguing ...

Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of ...

The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20^100 ...

This study reports an important and novel finding that TENT5A, an enzyme involved in fine-tuning poly(A) tail length on selected mRNAs, is required for proper enamel mineralization in mice. The ...

Proteins often function in pairs or groups, concealing their internal connection points and making it difficult for ...

Age-related changes in protein tagging and degradation may help explain how the brain declines over time and why diet can still influence these processes.

Cryo-electron microscopy (cryo-EM) is a key technology for determining the structures of proteins, particularly large protein complexes. However, automatically building high-accuracy protein ...

Polygalacturonases (PG) are recognized as key cell-wall-degrading enzymes in phytopathogenic fungi. Plants have a well-developed defense mechanism to counter invasive pathogens, yet such attacks harm ...