Although the participation of spliceosomes is almost always required for intron removal, a few types of genes have ...

Researchers at Yale School of Medicine said they’ve solved a longstanding mystery of how mutations in the C9ORF72 gene, a common genetic cause of amyotrophic lateral sclerosis (ALS), may lead to toxic ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which ...

Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...

Although you may not appreciate them, or have even heard of them, throughout your body, countless microscopic machines called spliceosomes are hard at work. As you sit and read, they are faithfully ...

To carry out all of life’s functions, proteins must be produced from instructions carried by genes within DNA and delivered to the cell’s protein-making machinery by messenger RNA. However, to ...

iNtRON Biotechnology has announced that they have signed an “EVALUATION LICENSE AND OPTION AGREEMENT” with Basilea Pharmaceutica Ltd, Allschwil, granting Basilea the option to enter into an exclusive ...

Eukaryotic genes are interrupted by introns that are removed from transcribed RNAs by splicing. Patterns of splicing complexity differ between species, but it is unclear how these differences arise.

The human genome is just over 6 feet 8 inches long, which is 2 inches taller than the average NBA basketball player and in total, a lot of nucleotides! But what if the amount of sequence diversity ...