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Acemannan is the primary bioactive polysaccharide in aloe vera, and it interacts with the immune system in a very specific, measurable way. It doesn’t “stimulate” immunity the way herbs do; instead, it works as an immune-modulating compound. Its acetylated mannose chains bind to pattern-recognition receptors on macrophages, helping them recalibrate how they communicate with the rest of the immune network. (Think of it like updating your phone but this time it’s your immune system) When macrophag